Integrated personalized cell technologies for improving health outcomes in children and adults

Pilot Study of autologous MSCs for Radiation-Induced Xerostomia (Dry Mouth) in Head and Neck Cancer Patients Completed

The UW Program for Advanced Cell Therapy has completed enrollment for the pilot MARSH (Marrow-derived Autologous Stromal cells for the Restauration of Salivary Hypofunction) clinical trial.

Six patients with radiation-induced Xerostomia (Dry Mouth) were treated in the pilot study led by Randall Kimple. The therapy delivers a single dose of GMP-manufactured, autologous Interferon gamma-stimulated bone marrow-derived mesenchymal stromal cells (MSCs) delivered “fresh” into one submandibular salivary gland.

Results from the study will be used to inform the safety and tolerability for feasibility of a UW Program for Advanced Cell Therapy-sponsored Phase 1, dose escalation clinical trial that includes 24 to 30 additional patients. Salivary gland function will be used to evaluate efficacy.

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